货品编号： BIOXCELL.BE0189-1mg 品牌：BIOXCELL 品名：anti-human CD40 规格：1mg

产品描述：

The G28.5 monoclonal antibody reacts with human CD40 also known as Bp50. CD40 is a 48 kDa type I transmembrane

glycoprotein that belongs to the tumor necrosis factor receptor (TNFR) superfamily. CD40 is expressed broadly on

antigen-presenting cells (APCs) such as dendritic cells, B cells, macrophages, and monocytes as well as non-immune

endothelial cells, basal epithelial cells, and a range of tumors. Upon binding to its ligand CD154, CD40 acts as a costimulatory

molecule for the activation of B cells, dendritic cells, monocytes, and other APCs. CD40 plays roles in B cell activation,

differentiation, proliferation and Ig isotype switching as well as dendritic cell maturation. Agonistic CD40 monoclonal antibodies

have been shown to activate APCs and promote anti-tumor T cell responses. The G28.5 antibody is an agonistic antibody that

has been shown to activate CD40 expressing APCs.