产品描述： background: This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide

linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects,

including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth,

promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known

as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic

retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been

characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame

with the first AUG, leading to additional isoforms.