货品编号： Thermo.11-0349-42 品牌：Thermo 品名：CD34 Monoclonal Antibody （4H11），FITC, eBIOSCENCETM 规格：100tests

产品描述：

Product Specific Information Description: The 4H11 monoclonal antibody reacts with human CD34, also known as mucosialin. CD34 belongs to

a protein family which also includes endoglycan and podocalyxin. Members of this family are single pass

transmembrane proteins with a heavily glycosylated extracellular and N-terminal mucin domain. CD34 was first

identified as an antigen expressed on hematopoietic progenitors, and has since been extensively used as a marker

to isolate cells capable of hematopoietic cell engraftment. In spite of this, the function of CD34 remains unresolved.

In addition to expression on hematopoietic progenitors, CD34 is expressed on some populations of mesenchymal

stem cells, tumor cell lines, and by vascular endothelia in the adult. Epitopes of CD34 have been assigned to three

classes (class I, II or III) based on their differential sensitivity to enzymatic cleavage by neuraminidase, chymopapain,

or O-glycoprotease. According to this analysis, the 4H11 antibody belongs to class III, indicating that it reacts with a

protein epitope.