货品编号： Biolegend351316 品牌：Biolegend 品名：APC anti-human CD127 (IL-7Rα) 规格：100 tests

产品描述： Description

CD127 is a 60-90 kD type I transmembrane glycoprotein also known as IL-7 receptor α chain or IL-7Rα.

It forms a heterodimer with the common γ chain (γc or CD132) which is shared with the receptors for IL-2,

IL-4, IL-9, IL-13, IL-15, and IL-21. CD127 is expressed on immature B cells through early pre-B stage cells,

thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, and bone marrow stromal cells.

CD127 has been reported to be a useful marker for identifying memory and effector T cells. Studies have

shown that CD127 expression is down-modulated on Treg cells. It can be used as a marker for differentiation

of Treg and conventional T cells. The ligation of IL-7 with its receptor is important for stimulation of mature and

immature T cells as well as immature B cell proliferation and development.