货品编号： 博奥森.bs-10937R

品牌：博奥森

品名：环指蛋白111抗体

规格：100ul

产品描述：

background: The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein

interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the

ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby

enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene

plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of

this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]