货品编号： biolegend.302914 品牌：biolegend 品名：LEAF™ Purified anti-human CD28 规格：500ug

产品描述： Description CD28 is a 44 kD disulfide-linked homodimeric type I glycoprotein. It is a member of the

immunoglobulin superfamily and is also known as T44 or Tp44. CD28 is expressed on most T lineage

cells, NK cell subsets, and plasma cells. CD28 binds both CD80 and CD86 using a highly conserved

motif MYPPY in the CDR3-like loop. CD28 is considered a major co-stimulatory molecule, inducing T

lymphocyte activation and IL-2 synthesis, and preventing cell death. In vitro studies indicate that ligation

of CD28 on T cells by CD80 and CD86 on antigen presenting cells provides a costimulatory signal

required for T cell activation and proliferation.