货品编号: Thermo.12-0388-42 品牌:Thermo 品名:CD38 Monoclonal Antibody (HB7), PE, eBioscience™ 规格: 100tests
产品描述: Product Specific Information Description: The HB7 monoclonal antibody reacts with the human CD38 molecule, an approximately 45 kDa type II transmembrane
protein. CD38 is an ectoenzyme which catalyses NAD into nicotinic acid adenine dinucleotide phosphate (NAADP) and cyclic ADP-
ribose (cADPR), both of which are secondary messengers. Expression of CD38 is bimodal during B cell development, modulating from
high in immature cells to low in intermediate ones and back to high on mature B cells. Additionally CD38 is found in a variety of tissues
and other hematopoietic cells (e.g. T cells, NK cells and monocytes) and can be used to phenotype leukemias and monitor HIV-1
progression. The CD34+CD38- population of hematopoietic stems cells is thought to define the most pluripotent cells (e.g. blast colony
forming cells). In addition to surface expression, CD38 has recently been found in the nucleus where it may play a role in monitoring
calcium levels.
特别声明:以上内容(如有图片亦包括在内)来源于授权厂家或网络,如有侵权,请联系客服删除,本平台不提供信息校正和存储服务。
Notice: The content above (including the pictures if any)comes from authorized manufacturers or networks. In case of infringement, please contact to delete it. This platform does not provide information storage services.