货品编号： Thermo.12-0388-42 品牌：Thermo 品名：CD38 Monoclonal Antibody (HB7), PE, eBioscience™ 规格： 100tests

产品描述： Product Specific Information Description: The HB7 monoclonal antibody reacts with the human CD38 molecule, an approximately 45 kDa type II transmembrane

protein. CD38 is an ectoenzyme which catalyses NAD into nicotinic acid adenine dinucleotide phosphate (NAADP) and cyclic ADP-

ribose (cADPR), both of which are secondary messengers. Expression of CD38 is bimodal during B cell development, modulating from

high in immature cells to low in intermediate ones and back to high on mature B cells. Additionally CD38 is found in a variety of tissues

and other hematopoietic cells (e.g. T cells, NK cells and monocytes) and can be used to phenotype leukemias and monitor HIV-1

progression. The CD34+CD38- population of hematopoietic stems cells is thought to define the most pluripotent cells (e.g. blast colony

forming cells). In addition to surface expression, CD38 has recently been found in the nucleus where it may play a role in monitoring

calcium levels.