产品描述： background: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple

biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription

regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus

mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor

alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced

apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this

gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Five alternatively spliced

transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jun 2013]