产品描述： background: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins,

including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles

in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and

adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and

smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the

myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the

same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms

have been found for this gene. [provided by RefSeq, Jul 2008]