产品描述： The extensive family of COL gene products (collagens) is composed of several chain types, including fibril-forming interstitial

collagens (types I, II, III and V) and basement membrane collagens (type IV), each type containing multiple isoforms.

Collagens are fibrous, extracellular matrix proteins with high tensile strength and are the major components of connective tissue,

such as tendons and cartilage. All collagens contain a triple helix domain and frequently show lateral self-association in order to

form complex connective tissues. Several collagens also play a role in cell adhesion, important for maintaining normal tissue

architecture and function.

This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such

as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are

associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use

of alternate polyadenylation signals, have been identified for this gene.