货品编号：博奥森.bs-0708R-100ul

品牌：博奥森

品名：高分子量神经丝蛋白抗体

规格：100ul

产品描述：

Neurofilaments can be defined as the intermediate or 10nm filaments found in specifically in neuronal cells.

When visualised using an electron microscope, neurofilaments appear as 10nm diameter fibres of

indeterminate length that generally have fine wispy protrusions from their sides. They are particularly

abundant in axons of large projection neurons. They probably function to provide structural support for

neurons and their synapses and to support the large axon diameters required for rapid conduction of

impulses down axons. Neurofilaments are composed of a mixture of subunits, which usually includes

the three neurofilament triplet proteins neurofilament light (NFL), neurofilament medium (NFM) and

neurofilament heavy (NFH). Neurofilaments may also include smaller amounts of peripherin, alpha

internexin, nestin and in some cases vimentin. Antibodies to the various neurofilament subunits are

very useful cell type markers since the proteins are among the most abundant of the nervous system,

are expressed only in neurons, and are biochemically very stable. Some studies have shown that levels

of neurofilament heavy and neurofilament light are elevated in patients with Alzheimer's disease, frontotemporal

lobe dementia, and vascular dementia.