货品编号： bioss.bs-5146R 品牌：bioss 品名：Rabbit Anti-AKT3 antibody (bs-5146R) 规格：100ul

产品描述： Akt, protein kinase B (PKB), is a serine/threonine kinase which is involved in many cellular signaling pathways and acts as a

transducer of many functions initiated by growth factor receptors that activate phosphtidylinositol 3 kinase (PI 3 kinase). The

major activity of Akt/PKB is to mediate cell survival. Akt/PKB is also believed to be a critical factor in the genesis of cancer as

the tumor suppressor PTEN was found to antagonise PI3 kinase and Akt/PKB kinase activity. There are 3 known isoforms of

this enzyme in mammalian cells (1/alpha, 2/beta and 3/gamma). IGF1 leads to the activation of AKT3, which may play a role in

regulating cell survival. It is capable of phosphorylating several known proteins.

Function: AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which

regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through

serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been

reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays

an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the

key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis

with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression

of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis.