货品编号： bioss.bs-5209R 品牌：bioss 品名：Rabbit Anti-phospho-AKT3 (Ser472) antibody (bs-5209R) 规格：100ul

产品描述： Akt, protein kinase B (PKB), is a serine/threonine kinase which is involved in many cellular signaling pathways and

acts as a transducer of many functions initiated by growth factor receptors that activate phosphtidylinositol 3 kinase

(PI 3 kinase). The major activity of Akt/PKB is to mediate cell survival. Akt/PKB is also believed to be a critical factor

in the genesis of cancer as the tumor suppressor PTEN was found to antagonise PI3 kinase and Akt/PKB kinase

activity. There are 3 known isoforms of this enzyme in mammalian cells (1/alpha, 2/beta and 3/gamma). IGF1 leads

to the activation of AKT3, which may play a role in regulating cell survival. It is capable of phosphorylating several

known proteins.