产品描述： JMJD3 is a 1,679 amino acid nuclear protein that contains one JmjC domain and belongs to the highly conserved JmjC

domain-containing protein family. Functioning as a histone demethylase, JMJD3 uses iron and ascorbate as cofactors to

demethylate dimethylated and trimethylated Lys-27 residues of Histone H3, thereby playing an important role in the

modification of the histone code. Additionally, JMJD3 regulates posterior development and is involved in the inflammatory

response, specifically by mediating macrophage differentiation. JMJD3 is also thought to control the expression of

neurogenesis-related proteins and, via this regulatory mechanism, may be necessary for neural commitment during early

development. Two isoforms of JMJD3 exist due to alternative splicing events.

Function: Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code.

Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by

regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case

of inflammation by regulating gene expression and macrophage differentiation.