货品编号： bioss.0501R

品牌： bioss

品名： Rabbit Anti-JNK1 + JNK3 antibody(试用装)

规格： 10ul

产品描述：

JNK1(MAPK8) is a member of the MAP kinase family. MAP kinases act as an integration point

for multiple biochemical signals, and are involved in a wide variety of cellular processes such as

proliferation, differentiation, transcription regulation and development. This kinase is activated

by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early

gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor

alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also

involved in UV radiation induced apoptosis, which is thought to be related to cytochrome c-mediated

cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a

key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript

variants encoding distinct isoforms have been reported. JNK1 is activated by threonine and tyrosine

phosphorylation by either of two dual specificity kinases, MAP2K4 and MAP2K7. The JNK pathway

is critically involved in diabetes and levels are abnormally elevated in obesity. The cell-permeable

JNK inhibitory peptide may have promise as a therapeutic agent for diabetes.