货品编号： bioss.bs-4605r

品牌： bioss

品名： Rabbit Anti-MMP2 antibody (bs-4605R)

规格： 10ul

产品描述：

This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent

enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal

transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains

three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen

and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane.

This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with

no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in

multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation

of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome

and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript

variants encoding different isoforms. [provided by RefSeq, Oct 2014]