货品编码: 博奥森.bs-0081R 品牌:博奥森 品名:Rabbit Anti-Caspase-3 antibody (试用装) 规格:10ul
产品描述: The caspase family of cysteine proteases play a key role in apoptosis. Caspase 3 is the most extensively studied
apoptotic protein among caspase family members. Caspase 3 is synthesized as inactive pro enzyme that is processed
in cells undergoing apoptosis by self proteolysis and/or cleavage by other upstream proteases (e.g. Caspases 8, 9 and 10).
The processed form of Caspase 3 consists of large (17kDa) and small (12kDa) subunits which associate to form an active
enzyme. Caspase 3 is cleaved at Asp28 Ser29 and Asp175 Ser176. The active Caspase 3 proteolytically cleaves and activates
other caspases (e.g. Caspases 6, 7 and 9), as well as relevant targets in the cells (e.g. PARP and DFF). Alternative splicing of
this gene results in two transcript variants which encode the same protein. In immunohistochemical studies Caspase 3 expression
has been shown to be widespread but not present in all cell types (e.g. commonly reported in epithelial cells of skin, renal proximal
tubules and collecting ducts). Differences in the level of Caspase 3 have been reported in cells of short lived nature (eg germinal
centre B cells) and those that are long lived (eg mantle zone B cells). Caspase 3 is the predominant caspase involved in the cleavage
of amyloid beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Reacts with Caspase-3 subunit p17 and precursor.
Function: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves
poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins
(SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates
caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.
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