货品编码： 博奥森.bs-0127R 品牌：博奥森 品名：Rabbit Anti-Bax antibody (试用装) 规格：10ul

产品描述： The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or

pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as

an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion

channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by

the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which

encode different isoforms, have been reported for this gene. [provided by RefSeq, Jul 2008].

Function: Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein.

Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of

cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.