品牌： Bioss

品名： Anti-Z0-1

规格： 100ul

产品描述：

MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some

hematopoietic cell lineages. It is expressed on most secretory epithelium, including mammary gland and some

hematopoietic cells. It is expressed abundantly in lactating mammary glands and overexpressed abundantly in >90%

breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four cebB receptors and

localize with erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different

alternatively spliced variants. The major expressed form of MUC1 uses all seven exons and is a type 1 transmembrane

protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O glycosylated and

alterations in glycosylation have been shown in epithelial cancer cells.

Function:

The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide

a protective layer on epithelial cells against bacterial and enzyme attack.

The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-

protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly

or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines

cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses

TP53 activity.