品牌： Bioss

品名： Anti-Bcl-2

规格： 100ul

产品描述：

The Bcl-2 gene was isolated at the chromosomal breakpoint of t(14;18)-bearing follicular B cell lymphomas(1,2).

Bcl-2 blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic

cell lines following growth factor withdrawal (3,5).Bcl-2 appears to function in several subcellular locations yet lacks

any known motifs that would confer insight into its mechanism of action (6,7).A more recently identified protein,

designated Bax p21(i.e., Bcl-associated X protein ),has extensive amino acid homology with Bcl-2 and both

homodimerizes and forms heterodimers with Bcl-2(8). Overexpression of Bax accelerates apoptotic death induced

by cytokine deprivation in an IL-3 dependent cell line and Bax also counters the death repressor activty of Bcl-2(8).

Function:

Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells.

Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop

system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria

and/or by binding to the apoptosis-activating factor (APAF-1).