品牌： Bioss

品名： Anti-Claudin 1

规格： 100ul

产品描述：

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous

seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the

paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing

cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded

by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands.

Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq].

Function:

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion

activity.