品牌： bioss

品名： Rabbit Anti-SRXN1 antibody

规格： 50ul

产品描述：

Sulfiredoxin, also designated Sulfiredoxin-1 and chromosome 20 open reading frame 139 (C20orf139), is a cytoplasmic

antioxidant protein involved in signaling through catalytic reduction of oxidative modifications. It regulates peroxiredoxins

(PRXs), a family of proteins that reduce hydroperoxides, by reducing the conserved cysteine from sulfinic to sulfenic acid.

This impacts the role of PRX in the reduction of other downstream transcription factors and kinase signaling pathways.

The Sulfiredoxin protein specifically acts on the PRDX1, PRDX2, PRDX3 and PRDX4 peroxiredoxins, but not on PRDX5

or PRDX6. Sulfiredoxin acts as a phosphotransferase and an athioltransferase and is widely expressed, with highest levels

detected in lung, spleen, kidney and thymus tissues.

Function:

SRXN1 contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the

peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. It does not act on PRDX5 or PRDX6. SRXN1 may catalyze the reduction

in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.