品牌： Abclonal

品名： COL1A1 Rabbit pAb

规格： 50ul

产品描述：

This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one

alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea,

dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome

type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations

between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are

associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression

of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.