品牌： Abclonal

品名： VEGF Mouse mAb

规格： 50ul

产品描述：

This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a

disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is

essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal

embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with

tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as

Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes

1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described.

There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional

isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation

termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some

isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an

internal ribosome entry site.