货品编号： bioss.bs-3698R 品牌：bioss 品名：Rabbit Anti-PML Protein antibody 规格：100UL/支
产品描述： The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three
zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein
localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-
cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation
with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative
splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the
same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.
Function:
Key component of PML nuclear bodies that regulate a large number of cellular processes by facilitating post-translational modification of target proteins, promoting protein-protein contacts, or by sequestering proteins. Functions as tumor suppressor.
Required for normal, caspase-dependent apoptosis in response to DNA damage, FAS, TNF, or interferons. Plays a role in
transcription regulation, DNA damage response, DNA repair and chromatin organization. Plays a role in processes regulated by
retinoic acid, regulation of cell division, terminal differentiation of myeloid precursor cells and differentiation of neural progenitor
cells. Required for normal immunity to microbial infections. Plays a role in antiviral response. In the cytoplasm, plays a role in
TGFB1-dependent processes. Regulates p53/TP53 levels by inhibiting its ubiquitination and proteasomal degradation. Regulates
activation of p53/TP53 via phosphorylation at 'Ser-20'. Sequesters MDM2 in the nucleolus after DNA damage, and thereby inhibits
ubiquitination and degradation of p53/TP53.
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