货品编号： bioss.bs-6319R 品牌：bioss 品名：Rabbit Anti-IL-1 Beta antibody 规格：20ul/支

产品描述： The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by

activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE).

This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities,

including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this

cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and

eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008].

Function: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation

and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being

identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from

synovial cells.