货品编号： bioss.bs-0169R-20ul 品牌：bioss 品名：Rabbit Anti-Caspase-1 P10 antibody 规格：20ul/支

产品描述： This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential

activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive

proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and

small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and

activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic

shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various

developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease.

Alternative splicing of this gene results in five transcript variants encoding distinct isoforms. [provided by RefSeq].

Function: Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in

a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory

element binding proteins (SREBPs). Can also promote apoptosis.

Subunit: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a

10 kDa (p10) subunit. The p20 subunit can also form a heterodimer with the epsilon isoform which then has an inhibitory

effect. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and NALP2

and whose function would be the activation of proinflammatory caspases. Interacts with CARD17/INCA and CARD18.