货品编号： BioXcell.BE0131-50MG

品牌： BioXcell

品名：InVivoMab. anti-mouse CTLA-4 (CD152)

规格： 50 mg

产品描述：

The 9H10 monoclonal antibody reacts with mouse CTLA-4 (cytotoxic T lymphocyte antigen-4) also known

as CD152. CTLA-4 is a 33 kDa cell surface receptor encoded by the Ctla4 gene that belongs to the CD28

family of the Ig superfamily. CTLA-4 is expressed on activated T and B lymphocytes. CTLA-4 is structurally

similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to the B7 family members B7-1

(CD80) and B7-2 (CD86). Upon ligand binding, CTLA-4 negatively regulates cell-mediated immune responses.

CTLA-4 plays roles in induction and/or maintenance of immunological tolerance, thymocyte development, and

regulation of protective immunity. The critical role of CTLA-4 in immune down-regulation has been demonstrated

in CTLA-4 deficient mice, which succumb at 3-5 weeks of age due to the development of a lymphoproliferative

disease. CTLA-4 is among a group of inhibitory receptors being explored as cancer treatment targets through

immune checkpoint blockade. The 9H10 antibody has been shown to promote T cell co-stimulation by blocking

CTLA-4 binding to the B7 co-receptors, allowing for CD28 binding.