品牌： BioXcell

品名： InVivoMab anti- mouse （CD25-2Rc)

规格： 50 mg

产品描述：

The PC-61.5.3 monoclonal antibody reacts with mouse IL-2Rα also known as CD25, Ly-43, p55, or Tac.

IL-2Rα is the 55 kDa ligand-binding subunit of the interleukin 2 receptor alpha chain. IL-2Rα is expressed

on activated mature T and B lymphocytes, thymocyte subsets, pre-B cells, and T regulatory cells. IL-2Rα

has been shown to play roles in lymphocyte differentiation, activation, and proliferation. Alone, the IL-2Rα

binds IL-2 with relatively low affinity however, when IL-2Rα associates with IL-2Rβ (CD122) and the common

gamma chain (CD132) the complex binds IL-2 with high affinity. The PC-61.5.3 antibody has been shown to

inhibit the binding of IL-2 to both the low and high affinity IL-2 receptor forms. Additionally, the PC-61.5.3

antibody is commonly used to deplete CD4+FoxP3+ T regulatory cells in vivo.