货品编号： BioXcell.BE0146-50MG

品牌： BioXcell

品名： InVivoMab anti- mouse. PD- 1 (CD279)

规格： 50 mg

产品描述：

The RMP1-14 monoclonal antibody reacts with mouse PD-1 (programmed death-1) also known as CD279.

PD-1 is a 50-55 kDa cell surface receptor encoded by the Pdcd1 gene that belongs to the CD28 family of the

Ig superfamily. PD-1 is transiently expressed on CD4 and CD8 thymocytes as well as activated T and B

lymphocytes and myeloid cells. PD-1 expression declines after successful elimination of antigen. Additionally,

Pdcd1 mRNA is expressed in developing B lymphocytes during the pro-B-cell stage. PD-1’s structure includes

a ITIM (immunoreceptor tyrosine-based inhibitory motif) suggesting that PD-1 negatively regulates TCR signals.

PD-1 signals via binding its two ligands, PD-L1 and PD-L2 both members of the B7 family. Upon ligand binding,

PD-1 signaling inhibits T-cell activation, leading to reduced proliferation, cytokine production, and T-cell death.

Additionally, PD-1 is known to play key roles in peripheral tolerance and prevention of autoimmune disease in

mice as PD-1 knockout animals show dilated cardiomyopathy, splenomegaly, and loss of peripheral tolerance.

Induced PD-L1 expression is common in many tumors including squamous cell carcinoma, colon adenocarcinoma,

and breast adenocarcinoma. PD-L1 overexpression results in increased resistance of tumor cells to CD8 T cell

mediated lysis. In mouse models of melanoma, tumor growth can be transiently arrested via treatment with

antibodies which block the interaction between PD-L1 and its receptor PD-1. For these reasons anti-PD-1

mediated immunotherapies are currently being explored as cancer treatments. Like the J43 antibody the

RMP1-14 antibody has been shown to block the binding of both mouse PD-L1-Ig and mouse PD-L2-Ig to PD-1.