规格：100ul

研究领域 细胞生物免疫学染色质和核信号微生物学信号转导新陈代谢表观遗传学 抗体来源 Rabbit 克隆类型 Polyclonal 交叉反应 Human,Mouse,Dog,Pig,Horse,Rabbit, 产品应用 WB=1:500-2000ELISA=1:500-1000IHC-P=1:100-500IHC-F=1:100-500Flow-Cyt=1ug/TestIF=1:100-500（石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分子量 81kDa 细胞定位 细胞核细胞浆 性状 Liquid 浓度 1mg/ml 免疫原 KLH conjugated synthetic peptide derived from human NAD-dependent protein deacetylase sirtuin-1:551-650/747 亚型 IgG 纯化方法 affinity purified by Protein A 储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. PubMed PubMed

产品介绍

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are

characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined;

however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest

that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded

by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.

Function: SirtT1 75 kDa fragment: catalytically inactive 75SirT1 may be involved in regulation of apoptosis. May be involved in protecting chondrocytes

from apoptotic death by associating with cytochrome C and interfering with apoptosome assembly.