规格：100ul

研究领域 细胞生物神经生物学信号转导生长因子和激素转录调节因子细胞因子 抗体来源 Rabbit 克隆类型 Polyclonal 交叉反应 Human,Mouse,Rat,Pig,Cow,Horse,Rabbit, 产品应用 WB=1:500-2000ELISA=1:500-1000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分子量 13/27kDa 细胞定位 细胞核分泌型蛋白 性状 Liquid 浓度 1mg/ml 免疫原 Recombinded human BDNF protein:129-247/247 亚型 IgG 纯化方法 affinity purified by Protein A 储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. PubMed PubMed

产品介绍

Neurotrophins function to regulate naturally occurring cell death of neurons during development. The prototype neurotrophin is nerve

growth factor (NGF), originally discovered in the 1950s as a soluble peptide promoting the survival of, and neurite outgrowth from,

sympathetic ganglia. More recently, three additional structurally homologous neurotrophic factors have been identified. These include

brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and neurotrophin-4 (NT-4), also designated NT-5. These various neurotrophins

stimulate the in vitro survival of distinct but partially overlapping populations of neurons. The Trk A receptor is the preferential receptor for

NGF, but also binds NT-3 and NT-4. The Trk B receptor binds equally well to both BDNF and NT-4 and to a lesser extent NT-3, while the Trk C

receptor only binds NT-3. BDNF promotes the survival of neuronal populations that are all located either in the central nervous system or directly

connected to it. Belongs to the NGF-beta family.