品牌： Bioss

品名： Anti-AKT1蛋白激酶B抗体

规格：100ul

研究领域 肿瘤 细胞生物 信号转导 细胞凋亡 激酶和磷酸酶

抗体来源 Rabbit

克隆类型 Polyclonal

交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep,

产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=2μg/Test ICC=1:100 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量 56kDa

细胞定位 细胞核 细胞浆 细胞膜

性 状 Liquid

浓 度 1mg/ml

免 疫 原 KLH conjugated synthetic peptide derived from human PKB:401-479/479

亚 型 IgG

纯化方法 affinity purified by Protein A

储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMed PubMed

产品介绍 The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved

primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The

activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown

that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator

of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner

by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic

machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript

variants have been found for this gene. [provided by RefSeq, Jul 2011]