货品编号： Bioss.bs-3210R 品牌：Bioss 品名：Anti-phospho-c-Jun (Ser63)磷酸化原癌基因c-Jun抗体 规格：100ul

产品类型 磷酸化抗体 研究领域 肿瘤免疫学信号转导转录调节因子 抗体来源 Rabbit 克隆类型 Polyclonal 交叉反应 Human,Mouse,Rat,Dog,Pig,Cow,Rabbit,Sheep, 产品应用 ELISA=1:500-1000IHC-P=1:100-500IHC-F=1:100-500Flow-Cyt=0.2μg /TestIF=1:100-500（石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分子量 43kDa 细胞定位 细胞核 性状 Liquid 浓度 1mg/ml 免疫原 KLH conjugated Synthesised phosphopeptide derived from human c-Jun around the phosphorylation site of Ser63:LT(p-S)PD 亚型 IgG 纯化方法 affinity purified by Protein A 储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. PubMed PubMed

产品介绍

The human protooncogene JUN is the putative transforming gene of avian sarcoma virus 17, and it encodes a protein which is highly homologous

to the viral protein. cJun (previously known as the Fos binding protein p39) and c Fos form a complex in the nucleus. AP 1 (activating protein 1) is

a collective term referring to these dimeric transcription factors composed of Jun, Fos or ATF subunits that bind to a common DNA site, the AP1

binding site. AP 1 proteins, mostly the Jun group, regulate the expression and function of cell cycle regulators such as Cyclin D1, p53, p21 (cip1/waf1),

p19 (ARF) and p16. Fos and Jun proto oncogene expression is induced transiently by a variety of extracellular stimuli associated with mitogenesis,

differentiation processes or depolarization of neurons. JUN has been mapped to 1p32 to p31, a chromosomal region involved in both translocations

and deletions in human malignancies.