货品编号： Bioss.bs-4163R 品 牌：Bioss 品 名：Anti-phospho-JNK1 + JNK2 + JNK3 (T183 + T183 + T221)磷酸化氨基末端激酶1/2/3抗体 规 格：100ul 产品类型 磷酸化抗体 研究领域 肿瘤信号转导转录调节因子 抗体来源 Rabbit 克隆类型 Polyclonal 交叉反应 Human,Mouse,Rat,Dog,Pig,Cow, 产品应用 WB=1:500-2000ELISA=1:500-1000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分子量 42kDa 细胞定位 细胞核细胞浆 性状 Liquid 浓度 1mg/ml

免疫原 KLH conjugated Synthesised phosphopeptide derived from human JNK1/JNK2/JNK3 around the phosphorylation site of T183/T

183/T221:MM(p-T)PY

亚型 IgG 纯化方法 affinity purified by Protein A 储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMed PubMed

产品介绍 The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple

biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation

and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-

early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be

required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related

to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in

T cell proliferation, apoptosis and differentiation. Five alternatively spliced transcript variants encoding distinct isoforms have been reported.

[provided by RefSeq, Jun 2013]