货品编号： Bioss.bs-3614R 品 牌：Bioss 品 名：Anti-PPAR alphaα型-过氧化酶活化增生受体抗体 规 格：100ul 研究领域 肿瘤免疫学信号转导转录调节因子激酶和磷酸酶 抗体来源 Rabbit 克隆类型 Polyclonal 交叉反应 Human,Mouse,Rat,Chicken,Pig,Cow,Horse,Rabbit, 产品应用 WB=1:500-2000ELISA=1:500-1000IHC-P=1:100-500IHC-F=1:100-500Flow-Cyt=2μg /testIF=1:100-500（石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分子量 51kDa 细胞定位 细胞核 性状 Liquid 浓度 1mg/ml 免疫原 KLH conjugated synthetic peptide derived from human PPAR alpha:301-400/468 亚型 IgG 纯化方法 affinity purified by Protein A 储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMed PubMed

产品介绍 Peroxisome proliferators are nongenotoxic carcinogens which are purported to exert their effect on cells through their interaction

with members of the nuclear hormone receptor family, termed Peroxisome Proliferator Activated Receptors (PPARs). Nuclear

hormone receptors are ligand dependent intracellular proteins that stimulate transcription of specific genes by binding to specific

DNA sequences following activation by the appropriate ligand. Studies indicate that PPARs are activated by peroxisome proliferators

such as clofibric acid, nafenopin, and WY-14,643, as well as by some fatty acids. It has also been shown that PPARs can induce

transcription of acyl coenzyme A oxidase and cytochrome P450 A6 (CYP450 A6) through interaction with specific response elements.

PPAR alpha is activated by free fatty acids including linoleic, arachidonic, and oleic acids. Induction of peroxisomes by this mechanism

leads to a reduction in blood triglyceride levels. PPAR alpha is expressed mainly in skeletal muscle, heart, liver, and kidney and is thought

to regulate many genes involved in the beta-oxidation of fatty acids. Activation of rat liver PPAR alpha has been shown to suppress

hepatocyte apoptosis. PPAR alpha, like several other nuclear hormone receptors, heterodimerizes with retinoic X receptor (RXR) alpha to

form a transcriptionally competent complex.