货品编号Bioss.bs-0623R

品牌Bioss

品名Anti-Cyclin D1周期素D1抗体

规格100ul

研究领域肿瘤 细胞生物 细胞周期蛋白

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Dog,

产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量32kDa

细胞定位细胞核 细胞浆 细胞膜

性 状Liquid

浓 度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human Cyclin D1:61-110/295

亚 型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMedPubMed

产品介绍The protein encoded by this gene belongs to the highly conserved cyclin family, whose members

are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins

function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation

patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a

complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required

for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein

Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and

overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety

of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008].