货品编号： Bioss.bs-4819RAnti-CD45 品 牌： Bioss 品 名： 白细胞共同抗原抗体 规 格： 100ul 研究领域 肿瘤细胞生物免疫学神经生物学信号转导干细胞转录调节因子细胞表面分子细胞类型标志物淋巴细胞t-淋巴细胞b-淋巴细胞 抗体来源 Rabbit 克隆类型 Polyclonal 交叉反应 Human,Mouse,Rat, 产品应用 WB=1:500-2000ELISA=1:500-1000IHC-P=1:100-500IHC-F=1:100-500Flow-Cyt=1μg/TestICC=1:100-500IF=1:50-200（石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分子量 137kDa 细胞定位 细胞膜 性状 Liquid 浓度 1mg/ml 免疫原 KLH conjugated synthetic peptide derived from rat CD45/B220:501-600/1273<Extracellular> 亚型 IgG 纯化方法 affinity purified by Protein A 储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMed PubMed

产品介绍 The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling

molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.

This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and

thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential

regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor

complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases,

and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode

distinct isoforms, have been reported. [provided by RefSeq, Jul 2008].