货品编号： Bioss.bs-4820R 品 牌： Bioss 品 名： Anti-CD45白细胞共同抗原抗体 规 格： 100ul 研究领域 肿瘤细胞生物免疫学神经生物学信号转导干细胞转录调节因子细胞表面分子淋巴细胞t-淋巴细胞b-淋巴细胞 抗体来源 Rabbit 克隆类型 Polyclonal 交叉反应 Human, 产品应用 ELISA=1:500-1000IHC-P=1:100-500Flow-Cyt=1μg/Test（石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分子量 145kDa 细胞定位 细胞膜 性状 Liquid 浓度 1mg/ml 免疫原 KLH conjugated synthetic peptide derived from human CD45/B220:401-500/1304<Extracellular> 亚型 IgG 纯化方法 affinity purified by Protein A 储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. PubMed PubMed

产品介绍 CD45 is a family of single chain transmembraneous glycoproteins consisting of at least four isoforms (220, 205, 190, 180 kDa)

which share a common large intracellular domain. Their extracellular domains are heavily glycosylated. The different isoforms

are produced by alternative messenger RNA splicing of three exons of a single gene on chromosome 1. CD45 is expressed on

cells of the human hematopoietic lineage (including hematopoietic stem cells) with the exception of mature red cells. It is not

detected on differentiated cells of other tissues. It is likely that CD45 plays an important role in signal transduction, inhibition or

upregulation of various immunological functions. Antibodies recognising a common epitope on all of the isoforms are termed CD45

whilst those recognising only individual isoforms are termed CD45RA or CD45RO etc.