货品编号Bioss.bs-0646R

品牌Bioss

品名Anti-CD34CD34抗体

规格100ul

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,

产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test IF=1:200-800 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量39kDa

细胞定位细胞膜

性 状Liquid

浓 度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human CD34:301-385/385 <Extracellular>

亚 型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMedPubMed

产品介绍The highly glycosylated 75-120 kD antigen CD34 is possibly an adhesion molecule with a putative role in

early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or

directly to stromal cells. It could act as a scaffold for the attachment of lineage specific glycans, allowing

stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to

have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is

a site of phosphorylation by activated protein kinase C, suggesting a putative role in signal transduction.

Two isoforms of CD34 have been reported to be generated by alternative splicing. CD34 is highly expressed

on hematopoietic progenitors, as well as on endothelial cells, brain, and testis. Staining for CD34 has been

used to measure angiogenesis, which reportedly predicts tumor recurrence.