货品编号Bioss.bs-0637R

品牌Bioss

品名Anti-P38 MAPK丝裂原活化蛋白激酶p38α抗体

规格100ul

研究领域肿瘤 免疫学 信号转导 细胞凋亡 转录调节因子

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Dog, Rabbit,

产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test ICC=1:100 IF=1:100-500 （

石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量41kDa

细胞定位细胞核 细胞浆

性 状Liquid

浓 度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human P38MAPK:141-240/360

亚 型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMedPubMed

产品介绍The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration

point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as

proliferation, differentiation, transcription regulation and development. This kinase is activated by various

environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP

kinase kinases(MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein

with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell

cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related

transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced

transcript variants of this gene encoding distinct isoforms have been reported.