货品编号Bioss.bs-0670R

品牌Bioss

品名Anti-C-jun原癌基因蛋白/活化蛋白1抗体

规格100ul

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep,

产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量43kDa

细胞定位细胞核 细胞浆

性 状Liquid

浓 度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human Transcription factor AP-1:31-331/331

亚 型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMedPubMed

产品介绍The human protooncogene JUN is the putative transforming gene of avian sarcoma virus 17, and

it encodes a protein which is highly homologous to the viral protein. cJun (previously known as the

Fos binding protein p39) and c Fos form a complex in the nucleus. AP 1 (activating protein 1) is a

collective term referring to these dimeric transcription factors composed of Jun, Fos or ATF subunits

that bind to a common DNA site, the AP1 binding site. AP 1 proteins, mostly the Jun group, regulate

the expression and function of cell cycle regulators such as Cyclin D1, p53, p21 (cip1/waf1), p19 (ARF)

and p16. Fos and Jun proto oncogene expression is induced transiently by a variety of extracellular

stimuli associated with mitogenesis, differentiation processes or depolarization of neurons. JUN has

been mapped to 1p32 to p31, a chromosomal region involved in both translocations and deletions in

human malignancies.