货品编号Bioss.bs-0718R

品牌Bioss

品名Anti-Smad2细胞信号转导分子Smad-2抗体

规格100ul

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit,

产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test ICC=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量52kDa

细胞定位细胞核 细胞浆

性 状Liquid

浓 度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human Smad2:21-120/467

亚 型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMedPubMed

产品介绍The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products

of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD

proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways.

This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple

cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the

TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein.

In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation

induces the dissociation of this protein with SARA and the association with the family member SMAD4. The

association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to

target promoters and forms a transcription repressor complex with other cofactors. This protein can also be

phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced

transcript variants have been observed for this gene. [provided by RefSeq, May 2012].