货品编号Bioss.bs-0842R

品牌Bioss

品名Anti-Myc tagc-Myc tag标签抗体

规格100ul

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Myc tag fused protein

产品应用WB=1:1000-5000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量49kDa

细胞定位细胞核

性 状Liquid

浓 度1mg/ml

免 疫 原KLH conjugated C-EQKLISEEDL (human Proto-oncogene c-Myc):

亚 型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMedPubMed

产品介绍Epitope tags are useful for the labeling and detection of proteins using immunoblotting, immunoprecipitation

and immunostaining techniques. Due to their small size, they are unlikely to affect the tagged protein's

biochemical properties. The Myc epitope tag is widely used to detect expression of recombinant proteins in bacteria,

yeast,insect and mammalian cell systems.

The c-Myc protein is a transcription factor, which is encoded by the c-Myc gene on human chromosome 8q24.

c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation,

differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and

previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen

synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminal Kinase (JNK) in cell proliferation and

cell cycle regulation. Studies also have shown that c-Myc is essential for tumor cell development in vasculogenesis

and angiogenesis that distribute blood throughout the cells, and which brought extensive attention in the development

of new therapeutic approach for cancer treatment.