货品编号Bioss.bs-10108R

品牌Bioss

品名Anti-phospho-Tau (Ser579)磷酸化微管相关蛋白抗体

规格100ul

研究领域细胞生物 免疫学 神经生物学

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Dog, Cow, Horse, Rabbit,

产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test ICC=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量52/79kDa

细胞定位细胞浆 细胞膜

性 状Liquid

浓 度1mg/ml

免 疫 原KLH conjugated synthesised phosphopeptide derived from human Tau protein around the phosphorylation site of Ser579:IG(p-S)TE

亚 型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMedPubMed

产品介绍Tau proteins are important Promotes microtubule assembly and stability, and might be involved in the establishment

and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural

plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is

predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome.

The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in

its stabilization. Tau proteins subcellular located in the axons of neurons, in the cytoso l and in association with plasma

membrane components. It expressed in neurons. PNS-tau is expressed in the peripheral nervous system while the

others are expressed in the central nervous system.