货品编号Bioss.bs-10113R

品牌Bioss

品名Anti-phospho-Tau (Thr522)磷酸化微管相关蛋白抗体

规格100ul

研究领域细胞生物 免疫学 神经生物学 信号转导

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Dog, Horse, Rabbit,

产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量52/79kDa

细胞定位细胞浆 细胞膜

性 状Liquid

浓 度1mg/ml

免 疫 原KLH conjugated synthesised phosphopeptide derived from human Tau protein around the phosphorylation site of Thr522:PG(p-T)PG

亚 型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMedPubMed

产品介绍Tau proteins are important Promotes microtubule assembly and stability, and might be involved in the

establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while

the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker

protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the

domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton

whereas the longer isoforms may preferentially play a role in its stabilization. Tau proteins subcellular

located in the axons of neurons, in the cytoso l and in association with plasma membrane components.

It expressed in neurons. PNS-tau is expressed in the peripheral nervous system while the others are

expressed in the central nervous system.