货品编号： bioss.bs-18069R-10ul 品 牌： Bioss 品 名：Rabbit Anti-HLA Class I A1 antibody 规 格： 10ul 研究领域 细胞生物免疫学细胞膜蛋白 抗体来源 Rabbit 克隆类型 Polyclonal 交叉反应 Human, 产品应用 WB=1:500-2000ELISA=1:500-1000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分子量 41kDa 细胞定位 细胞膜 性状 Liquid 浓度 1mg/ml 免疫原 KLH conjugated synthetic peptide derived from human HLA Class I A1:51-150/366<Extracellular> 亚型 IgG 纯化方法 affinity purified by Protein A 储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMed PubMed

产品介绍 HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain

and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in

the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells.

The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode

the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane

region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding

specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation.

Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008]