货品编号： Bioss.bsm-10825M 品 牌： Bioss 品 名：Anti-CD31血小板内皮细胞黏附分子1单克隆抗体 规 格： 100ul 研究领域 肿瘤心血管细胞生物免疫学干细胞细胞粘附分子血管内皮细胞内皮细胞 抗体来源 Mouse 克隆类型 Monoclonal 克隆号 3B5 交叉反应 Human, 产品应用 WB=1:100-1000IHC-P=1:100-500（石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分子量 78kDa 细胞定位 细胞膜 性状 Liquid 浓度 1mg/ml 免疫原 Recombinant human CD31 28-601/727aa (C-6x His-Tag):<Extracellular> 亚型 IgG 纯化方法 affinity purified by Protein A 储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMed PubMed

产品介绍 This protein is a cell adhesion molecule expressed on platelets and at endothelial cell intercellular junctions. Type I membrane

protein. SIZE: 738 amino acids; 82536 Da. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

TISSUE SPECIFICITY: Long isoform predominates all tissues examined, isoform Delta12 was detected only in trachea and

isoform Delta14-15 only in lung, isoform Delta14 was detected in all tissues examined with the strongest expression in heart.

PTM: Phosphorylated on Ser and Tyr residues after cellular activation. SIMILARITY: Contains 6 Ig-like C2-type (immunoglobulin-

like) domains. CD31, also known as platelet endothelial cell adhesion molecule 1 (PECAM1), is a type I integral membrane glycoprotein and a

member of the immunoglobulin superfamily of cell surface receptors. It is found on the surface of platelets, monocytes, neutrophils,

and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. CD31 is implicated in several functions,

including transendothelial migration of leukocytes, angiogenesis, and integrin activation. Tyr-690 plays a critical role in leukocyte

transendothelial migration (TEM) and is required for efficient trafficking of CD31 to and from the lateral border recycling compartment (LBRC)

and is also essential for the LBRC membrane to be targeted around migrating leukocytes. CD31 prevents phagocyte ingestion of closely

apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes

(the encounter of a viable cell with a phagocyte via the homophilic interaction of CD31 on both cell surfaces leads to the viable cell's active

repulsion from the phagocyte. During apoptosis, the inside-out signaling of CD31 is somehow disabled so that the apoptotic cell does not

actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective

receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). CD31 has been used to

measure angiogenesis in association with tumor recurrence. Other studies have also indicated that CD31 and CD34 can be used as markers

for myeloid progenitor cells and recognize different subsets of myeloid leukemia infiltrates (granular sarcomas).