货品编号： Bioss.bs-8453R 品 牌： Bioss 品 名：Anti-phospho-Tau (Thr181)磷酸化微管相关蛋白抗体 规 格： 100ul 研究领域 细胞生物免疫学神经生物学转录调节因子 抗体来源 Rabbit 克隆类型 Polyclonal 交叉反应 Human,Mouse,Rat,Dog,Cow,Horse,Rabbit, 产品应用 WB=1:500-2000ELISA=1:500-1000IHC-P=1:100-500IF=1:50-200（石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分子量 52/83kDa 细胞定位 细胞浆细胞膜 性状 Liquid 浓度 1mg/ml 免疫原 KLH conjugated synthesised phosphopeptide derived from human Tau protein around the phosphorylation site of Thr181:PK(p-T)PP 亚型 IgG 纯化方法 affinity purified by Protein A 储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. PubMed PubMed

产品介绍 Tau proteins are important Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of

neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting

that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain

of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially

play a role in its stabilization. Tau proteins subcellular located in the axons of neurons, in the cytoso l and in association with plasma membrane

components. It expressed in neurons. PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous

system.