货品编号Bioss.bs-1353R-100ul

品牌Bioss

品名Anti-Beclin 1Bcl-2同源结构域蛋白抗体

规格100ul

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,

产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量50kDa

细胞定位细胞浆 细胞膜

性 状Liquid

浓 度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human BECN1:201-330/450

亚 型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMedPubMed

产品介绍Beclin 1 is the first identified mammalian gene to mediate autophagy and also has tumor suppressor and

antiviral function. Autophagy, a process of bulk protein degradation through an autophagosomic lysosomal

pathway, is important for differentiation, survival during nutrient deprivation, and normal growth control, and

is often defective in tumor cells. Beclin 1 was originally isolated in a yeast two hybrid screen to identify Bcl

2 binding partners and maps to a tumor susceptibility locus on human chromosome 17q21 that is frequently

monoallelically deleted in human breast, ovarian and prostate cancer. Beclin 1 encodes an evolutionarily

conserved 52kDa coiled coil protein that is expressed in human muscle, epithelial cells and neurons.